On November 22nd, Ethereum founder Vitalik issued a message stating that in 2014 he published an article and a lecture on mathematics, computer science and economics. He considered these problems for encryption. The maturity of the currency sector is crucial. Now that five years have passed, the situation has changed a lot. Some of the 16 issues including cryptography, consensus theory, and economics have progressed, such as proof of equity, stable currency, decentralized public goods incentives, etc. Slow, such as consensus theory, code obfuscation, reputation systems, etc. Finally, V God mentioned that the underlying layer problem is slowly decreasing, but the application layer problem has just begun.